Upward bias in estimation of genetic effects.
نویسنده
چکیده
Because of the large number of tests for linkage that are performed in genome scans, the naive estimator of the size of a genetic effect in cases of borderline significance can be inflated and lead to unrealistic expectations for successful replication. As a remedy, this report proposes lower confidence limits that account for the multiple comparisons of the genome scan.
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ورودعنوان ژورنال:
- American journal of human genetics
دوره 71 5 شماره
صفحات -
تاریخ انتشار 2002